AML
        Prognostic index for adults with first relapse of acute myeloid leukemia
Prognosis of relapsed AML       Applies to adult patients aged 15 – 60 years with acute myeloid leukemia (except acute promyelocytic leukemia) in first relapse.        
        1. Sum the points for each risk factor        
Value Points
Prognostic factor 0 points 1 point 2 points 3 points 5 points
Duration of remission prior to relapse (months)
Duration of remission prior to relapse (months) > 18 - - 7 - 18 < 7
Cytogenetics at initial diagnosis
Cytogenetics at initial diagnosis inv(16) or t(16;16) - - t(8;21) other
Prior hematopoietic stem cell transplantation
Prior hematopoietic stem cell transplantation NO - YES - -
Age at time of relapse (years)
Age at time of relapse (years) ≤ 35 36 - 45 > 45 - -
2. Assign risk category and determine prognosis
Score Category % of patients 1 yr OS 5 yr OS
Prognostic index   0 - 6 9% 70% 46%  
Risk category   7 - 9 25% 49% 18%  
10 - 14 66% 16% 4%
Reference
Breems DA, Van Putten WL, Huijgens PC, Ossenkoppele GJ, Verhoef GE, Verdonck LF et al. Prognostic index for adult patients with acute myeloid leukemia in first relapse. J Clin Oncol 2005; 23: 1969-1978.