Essential thrombocythemia International Prognostic Score for Thrombosis in Essential Thrombocythemia (ET) IPSET-thrombosis Value Points 1. Calculate IPSET-thrombosis score Age (years)* Patient age? under 60 years 60 years or older Prior thrombosis -Please Select No Yes Prior thrombotic event? No Yes Cardiovascular risk factors* -Please Select No Yes Cardiovascular risk factors present? No Yes JAK2V617F mutation -Please Select No Yes JAK2 V617F mutation detected? No Yes *One or more of: hypertension, diabetes mellitus, active smoking One or more of: hypertension, diabetes mellitus, active smoking IPSET-thrombosis score: IPSET-thrombosis score 2. Determine risk group and prognosis IPSET-thrombosis risk group Score Risk category Annual thrombosis risk 0 - 1 Low 1.03% 2 Intermediate 2.35% 3 - 6 High 3.56% Reference Barbui T, Finazzi G, Carobbio A, Thiele J, Passamonti F, Rumi E et al. Development and validation of an International Prognostic Score of thrombosis in World Health Organization-essential thrombocythemia (IPSET-thrombosis). Blood 2012; 12: 5128-33.