ISS
  International Staging System (ISS) for Symptomatic Myeloma    
            Prognostic score for newly-diagnosed symptomatic myeloma
                   
Value
ISS stage1 Criteria Five year OS2
β2-microglobulin mg/L
I β2-microglobulin < 3.5 mg/L (< 296 nmol/L) AND albumin ≥ 35 g/L 66
albumin g/L
II Not meeting criteria for stage I or III 45
III β2-microglobulin > 5.5 mg/L 18
Stage