Lugano
NHL CT-BASED RESPONSE ASSESSMENT (LUGANO 2014)
  VALUE
LYMPH NODES (dominant)
BASELINE: > 1,5 CM
CR: All regressed to <=1,5 cm
Cru: Residual nodes > 1.5 cm but >75% regression of the product of the longest perpendicular dimensions
PR: 50% or greater dicrease in the sum of the products of the longest perpendicular dimensions of the previously identified dominant lymph node mass
LYMPH NODES (non-dominant, measurable)
BASELINE: 1-1,5 cm
CR: All regressed to <1cm or regression >75% regression in the product of the longest perpendicular dimensions
Cru: Residual nodes > 1.5 cm but >75% regression of the product of the longest perpendicular dimensions
PR: 50% or greater dicrease in the sum of the products of the longest perpendicular dimensions of the previously identified dominant lymph node mass
LYMPH NODES (assessable)
BASELINE: --
CR: no new sites of lymphoma appeared
Cru: no new sites of lymphoma appeared
PR: no new sites of lymphoma appeared
SPLEEN
BASELINE: Elarged (>13 cm longitudinal diameter) or involved (nodules)
CR: All nodules resolved & normal size
Cru: All nodules resolved & normal size
PR: Regression >= 50% in the sum of the products of the longest perpendicular dimensions of any nodule & no increse in size
LIVER
BASELINE: Nodules
CR: all nodules resolved
Cru: all nodules resolved
PR: Regression >= 50% in the sum of the products of the longest perpendicular dimensions of any nodule & no increse in size
BONE MARROW
BASELINE: Involvement
CR: Biopsy cleared
Cru: Increased number of size of lymphoid aggregates withput cytological aor achitectural atypia
PR: Na
SYMPOMS
BASELINE: B-symptoms
CR: Disappearance of all symptoms
Cru: Disappearance of all symptoms
PR: Na
LAB
BASELINE: Abnormal tests (LDH and others)
CR: Normal LDH, no lab abnormalities due to lymphoma
Cru: Normal LDH, no lab abnormalities due to lymphoma
PR: Na
RESPONSE LUGANO
CLASSI DI RISPOSTA:
1) COMPLETE REMISSION GLOBALE richiede CR in tutti i 5 campi (oppure assenza di anomalie al BASELINE)
2) COMPLETE REMISSION UNDEFINED GLOBALE richiede CRu in tutti i campi
3) PARTIAL RESPONSE richiede PR in tutti i campi
Reference: Cheson-B et al. Recommendations of initial evaluation, staging and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 2014;32:3059-3067