CLL immunophenotypic score (Matutes score)          
          Immunophenotypic score for diagnosis of chronic lymphocytic leukemia
          Flow cytometric analysis of peripheral blood or bone marrow is performed for expression of the cell surface markers listed in the table below. The scores for each marker are summed.
  Value Points     Cell surface marker 0 points 1 point
CD79b (or CD22)
    CD79b (or CD22) Strong Weak
CD23 Negative Positive
    CD5 Negative Positive
    FMC7 Positive Negative
    SmIg Strong Weak
Sum of score       A score 4 is indicative of CLL. A score of 3 should prompt consideration of an alternative diagnosis,
1. Matutes E, Owusu-Ankomah K, Morilla R, Garcia Marco J, Houlihan A, Que TH et al. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia 1994; 8: 1640-5.
2. Moreau EJ, Matutes E, A’Hern RP, Morilla AM, Morilla RM, Owusu-Ankomah KA et al. Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b). Am J Clin Pathol 1997; 108: 378-382.