Mantle Cell Lymphoma International Prognostic Index Combined Biologic Index (MIPIb) Calculator Combined biologic index for prognosis of advanced stage mantle cell lymphoma, incorporating Ki67 proliferation index. Value Points Age (years) Applied at the time of diagnosis. If Ki67 is not available, use the MIPI index. LDH (U/L) The MIPIb score is is calculated using the formula: [0.03535 x age (years)] + 0.6978 (if ECOG > 1) + [1.367 x log10(LDH/ULN)] + [0.9393 x log10(WBC count)] + [0.02142 x Ki-67 (%)]. Upper limit of normal for serum LDH (U/L) white blood cell count (x 109/L) ECOG Performance status Ki67 proliferation index (%) Sum of score A score < 5.7 indicates low risk disease, 5.7 - 6.5 indicates intermediate risk, and 6.5 or greater high risk. Risk category References Hoster E, Dreyling M, Klapper W, Gisselbrecht C, van Hoof A, Kluin-Nelemans HC et al. A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. Blood 2008; 111: 558-565.