Infezioni Batteriche - Siematologia

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Infezioni Batteriche

LINEE GUIDA > Linee Guida > capitolo10
infezioni batteriche
REFERENZE >> KPC- KPC+ DURATA ATTESA della NEUTROPENIA (ANC<500/mmc) < 7 giorni  ANZIANO ad alto rischio infettivo > 7 giorni < 7 giorni
1. Usually the choice of drug to be used for antibiotic prophylaxis takes into account the prerogative not to influence, either positively or negatively, the effectiveness of the treatment of the underlying malignancy. However we must take into account that fluoroquinolones (particularly ciprofloxacin) are "moderate” inhibitors CYP3A4 which represents the substrate of some drugs such as daunorubicin, etoposide, cyclophosphamide, vinca alkaloids, even if there are not relevant clinical data. It could be probably best to suggest beginning prophylaxis after chemotherapy.
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