Mielofibrosi:candidati a ruxolitinib - Siematologia

“Symptomatic” splenomegaly refers to the concurrent presence of a splenomegaly and local symptoms not attributable to other causes, such as pain in the left upper quadrant of the abdomen, or impairment of food intake due to early satiety.

“Severe” splenomegaly refers to splenomegaly palpable 15 cm below the  costal margin.