International Prognostic Scoring System for Waldenström macroglobulinemia (ISSWM)
Prognostic score for Waldenström macroglobulinemia (lymphoplasmacytic lymphoma with IgM paraprotein)  
Applies to symptomatic patients requiring first-line therapy.    
          1. Sum the number of risk factors      
Value Points
ISSWM risk factors
Age (years)
Age > 65 years (advanced age alone = intermediate risk)
hemoglobin (x g/dL)
Hemoglobin ≤ 11.5 g/dL
platelet count (x 109/L)
Platelet count ≤ 100 x109/L
Serum Β2-microglobulin (mg/L)
Serum Β2-microglobulin > 3 mg/L
Serum monoclonal protein (g/L)
Serum monoclonal protein > 70 g/L
          2. Determine risk category and prognosis      
Risk factors Risk category % of patients Median survival (months)
0 or 1 (except age) Low 27 142
Sum of score       Any 2, or age alone Inter­mediate 38 99
Risk category       ≥ 3 High 35 43
Morel P, Duhamel A, Gobbi P, Dimopoulos MA, Dhodapkar MV, McCoy J et al. International prognostic scoring system for Waldenstrom macroglobulinemia. Blood 2009; 113: 4163-4170.